Riluzole is used to treat amyotrophic lateral sclerosis (ALS; Lou Gehrig's disease). Amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND) is a fatal neurological disease which produces paralysis of the limb, swallowing and breathing muscles. Following pivotal clinical trials in amyotrophic lateral sclerosis (ALS), approval of riluzole by the US Food and Drug Administration in 1995 was met with optimism. The guidelines recommend riluzole regardless of disease stage because, as Dr. Miller explains, there is insufficient evidence to say who would benefit from it. As a result, scientists are developing ways to quickly test the effectiveness of other drugs against ALS. Riluzole is in a class of medications called benzothiazoles. No single drug or treatment should be viewed in isolation when dealing with ALS. Insurance can bring this cost down significantly. Although Riluzole - the first approved drug for ALS treatment - is believed to regulate the glutamate system, the therapeutic benefits of this drug are modest. However, many new therapies are being considered, are under development, or have undergone testing. In this review, we examine the evidence from four randomized clinical trials involving 1477 people with ALS. Arch Neurol. Questions persist about its clinical utility because of high cost, modest efficacy and concern over adverse effects. Background: Riluzole has been approved for treatment of patients with amyotrophic lateral sclerosis (ALS) in some countries but not others. You should not take TIGLUTIK if you are allergic to any of its ingredients. Riluzole is the only drug approved by the Food and Drug Administration (FDA) for ALS. Riluzole was approved in the United States for the treatment of ALS by the U.S. Food and Drug Administration (FDA) in 1995. 7 These therapies are placed into … It works by changing the activity of certain natural substances in the body that affect nerves and muscles. TIGLUTIK can cause liver injury, including death. However, the generic, riluzole, has a retail price per capsule without insurance of $3/pill. Rilutek is an orally swallowed pill. Very common (>10% frequency): nausea; weakness; decreased lung function amyotrophic lateral sclerosis treated with riluzole. Amyotrophic lateral sclerosis. Adverse effects. Medicare and the VA cover riluzole, and the National Organization for Rare Diseases can help support the cost if needed. Important Safety Information. It extends life by two or three months. 34. 1998;55(4):526-528. Riluzole, marketed as Rilutek, was the first treatment to be approved by the FDA for ALS in 1995. 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