Download conference presentations and read journal articles that review the use of APL-2 (pegcetacoplan) as a possible treatment for geographic atrophy (GA), paroxysmal nocturnal hemoglobinuria (PNH), cold agglutinin disease (CAD), and other autoimmune and inflammatory diseases. Review how overactivity of the immune system's complement cascade causes kidney damage, and how APL-2 (pegcetacoplan) may work a possible treatment. Pegcetacoplan was granted Fast Track designation by … The APL2-103 study is a Phase 1b, multicenter, open label, single arm, 24-month clinical trial to assess the safety of monthly intravitreal (IVT) injections of pegcetacoplan in patients diagnosed with advanced geographic atrophy (GA) secondary to age-related macular degeneration (AMD). Apellis plans to initiate a clinical trial in ALS to understand if targeting C3 with pegcetacoplan may have the potential to slow the progression of ALS by reducing the inflammation that causes motor neuron death. Retina Northwest is committed to fostering cutting edge treatments for retinal diseases through our participation in clinical trials. Apellis is evaluating pegcetacoplan in several clinical studies across hematology, ophthalmology, nephrology, and neurology. Clinical Trials at Retina Northwest. Apellis Pharmaceuticals, Inc, a clinical-stage biopharmaceutical company, focuses on the development of therapeutic compounds through the inhibition of the complement system for autoimmune and inflammatory diseases. Apellis to Showcase Leadership in Retina at Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting PRESS RELEASE GlobeNewswire Apr. We felt a responsibility to learn if controlling complement could help save lives during this devastating pandemic,” said Lukas Scheibler, Ph.D., chief innovation officer at Apellis. The primary outcome measures include incidence and severity of ocular and systemic treatment-emergent … Apellis has two ongoing Phase Ib proof-of-concept clinical trials evaluating APL-2 in PNH: PHAROAH and PADDOCK. Request a Demo. Investors: Argot Partners [email protected] 212.600.1902. Monitoring GA Lesion Size on Optical Coherence Tomography (OCT) Using Automated Deep Learning-Based Image Segmentation in the FILLY Phase 2 Clinical Trial – May 2, 11:15 a.m. - … Apellis is a global biopharmaceutical company that develops life-changing therapies. Read the policy on obtaining an Apellis investigational therapy outside of a clinical trial. This policy refers to a program for a patient with a serious, life threatening condition who has exhausted all available medical options and is unable to enroll in clinical trials. “We initiated the clinical development of APL-9 in patients with severe COVID-19 because we believed that complement dysregulation may play a key role in disease mortality. Apellis Pharmaceuticals has stopped development of APL-9 in severe COVID-19 patients after an interim review of phase 1/2 mortality data. Brief descriptions of our active clinical trials are listed below. Apellis is currently evaluating subcutaneous administration of APL-2 in PEGASUS, a Phase 3 trial for patients with PNH currently on treatment with eculizumab, as well as in two Phase 1b trials (PHAROAH and PADDOCK) in patients with PNH. Monitoring GA Lesion Size on Optical Coherence Tomography (OCT) Using Automated Deep Learning-Based Image Segmentation in the FILLY Phase 2 Clinical Trial … Access helpful resources and learn about the signs and symptoms of C3 glomerulopathy (C3G), a rare kidney disease. PIONEER is a clinical research study evaluating the investigational medication, pegcetacoplan, in adolescents who have been diagnosed with PNH. Pegcetacoplan is an investigational, targeted C3 therapy designed to regulate excessive activation of the complement cascade. Cedric Francois, Apellis CEO (Apellis) ... Bluebird Bio was forced to suspend clinical trials of its gene therapy for sickle cell disease after two patients in the trial developed cancer. Pegcetacoplan was granted Fast Track designation by the U.S. Food and Drug Administration (FDA) for the treatment of PNH and the treatment of GA. For additional information regarding our clinical trials, visit We deliver modern, flexible and validated randomization and trial supply management solutions to Pharma and CROs faster than anyone else in the world. About APL2-103 The APL2-103 study is a Phase 1b, multicenter, open label, single arm, 24-month clinical trial to assess the safety of monthly intravitreal (IVT) injections of pegcetacoplan in patients diagnosed with advanced geographic atrophy (GA) secondary to age-related macular degeneration (AMD). References Sobi Paula Treutiger, Head of … We believe the way to accelerate clinical research is to disrupt the way trials are executed. Apellis is evaluating pegcetacoplan in several clinical studies across hematology, ophthalmology, nephrology, and neurology. The PHAROAH trial is evaluating whether APL-2 can provide benefits to patients on treatment with eculizumab who are severely anemic and transfusion-dependent. Apellis Media: Lissa Pavluk [email protected] 617.977.6764. 16, 2021, 06:44 PM That's why we've revolutionized RTSM and supply forecasting capabilities and services from the ground-up. Apellis is evaluating pegcetacoplan in several clinical studies including paroxysmal nocturnal hemoglobinuria (PNH), geographic atrophy (GA), and C3 glomerulopathy. CRESTWOOD, Ky. and WALTHAM Mass., June 27, 2019 (GLOBE NEWSWIRE) -- Apellis Pharmaceuticals Inc., (Nasdaq:APLS) a clinical-stage biopharmaceutical company focused on the development of novel therapeutic compounds to treat disease through the inhibition of the complement system, today announced the completion of enrollment for its PEGASUS Phase 3 trial assessing the safety and … By pioneering targeted C3 therapies, we aim to treat diseases that are driven by excessive activation of the complement cascade, including those within hematology, ophthalmology, and nephrology. 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