Keywords: et al. In conclusion, the PGA was demonstrated to be a valid, responsive and feasible instrument, but its reliability was strongly impacted by the scale adopted, suggesting the need for standardization in its scoring. [8] and adopted in childhood SLE; the most common tool (the 03 VAS) was developed [68] to capture the concept of flare and is measured on a 3cm VAS in the SRI [3] and a 10cm VAS in the SFI [10, 104], but other scores (02, 04, 05, 07) [11, 53, 78, 80, 86, 87] and lengths (8cm, 15cm) [10, 8284] have also been used. Psychometric properties data were analysed according to the OMERACT Filter methodology version 2.1. , Annapureddy N , Koutsoviti S A total of 91 articles were included in the study (Fig. Manzi S Face validity. In the absence of a well-recognized gold standard for disease activity, criterion validity of the PGA is established when it correlates with a measure that the author of the study defined a priori as the gold standard. The patients were diagnosed as having the following disorders: scleroderma (n = 27), dermatomyositis (n = 11), systemic lupus erythematosus (SLE) (n = 22), MCTD (n = 8), and RP without evidence of underlying CTD (n = 38). Objective: Int J Environ Res Public Health. Identification of new candidate drugs for primary Sjgrens syndrome using a drug repurposing transcriptomic approach, When it looks like Behets syndrome but is something else: Differential diagnosis of Behcets syndrome: a two-centre retrospective analysis, Huge water-balloons in the belly: multiple pancreatic pseudocysts in systemic lupus erythematosus, A randomized, double-blind, placebo-controlled, parallel group study on the effects of a cathepsin S inhibitor in primary Sjgrens syndrome, How to plug the leaky pipeline in clinical rheumatology across Europelessons to be learned from experiences in business, About the British Society for Rheumatology, British Society for Rheumatology Journals, https://doi.org/10.1093/rheumatology/keaa383, https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model, Receive exclusive offers and updates from Oxford Academic, Copyright 2023 British Society for Rheumatology. , Hochberg M. Touma Z 3TR (Taxonomy, Treatment, Targets and Remission) Systemic Lupus Erythematosus Study Protocol 2 Pain assessment: An alternative measure - hcplive.com Objective Existing methods for grading lupus flares or improvement require definition-based thresholds as increments of change. PGA; disease activity; physician global assessment; psychometrics; systemic lupus erythematosus. Deconstruction of the safety of estrogen in lupus erythematosus national assessment-systemic lupus erythematosus disease activity index flare index, Effect of raloxifene on disease activity and vascular biomarkers in patients with systemic lupus erythematosus: subgroup analysis of a double-blind randomized controlled trial, Omega-3 in SLE: a double-blind, placebo-controlled randomized clinical trial of endothelial dysfunction and disease activity in systemic lupus erythematosus, Erythrocyte sedimentation rate is a predictor of renal and overall SLE disease activity, Characterization of clinical photosensitivity in cutaneous lupus erythematosus, Validation of the systemic lupus erythematosus responder index for use in juvenile-onset systemic lupus erythematosus, Depressive symptoms and associated factors in systemic lupus erythematosus, Validation of the Portuguese simple measure of impact of lupus erythematosus in youngsters (SMILEY) in Brazil, Anti-C1q antibodies have higher correlation with flares of lupus nephritis than other serum markers, Performance of anti-C1q, antinucleosome, and anti-dsDNA antibodies for detecting concurrent disease activity of systemic lupus erythematosus, An assessment of disease flare in patients with systemic lupus erythematosus: a comparison of BILAG 2004 and the flare version of SELENA, Noncalcified coronary plaque in systemic lupus erythematosus, Decreases in anti-double-stranded DNA levels are associated with concurrent flares in patients with systemic lupus erythematosus, Validity and reliability of lupus activity measures in the routine clinic setting, Clinical predictors of response and discontinuation of belimumab in patients with systemic lupus erythematosus in real life setting. , Gladman DD Physician global assessment in systemic lupus erythematosus: can we Global Automatic Chemiluminescence Immunoassay Analyzer Market 2023 The .gov means its official. , Bertsias G Physician Global Assessment (PGA) is a visual analogue score (VAS) that reflects the clinician's judgment of overall Systemic Lupus Erythematosus (SLE) disease activity. The SRI is a composite instrument comprised of the SELENA-SLE Disease Activity Index [SELENA-SLEDAI], Physician Global Assessment (PGA) and British Isles Lupus Assessment Group (BILAG) 2004. Exagen's products are used for therapeutic drug monitoring of hydroxychloroquine in whole blood and methotrexate polyglutamates, risk assessment testing, anti-TNF monitoring to individualize therapy and optimize dosing, and others. BILAGAB . Clinical Trial on Systemic Lupus Erythematosus (SLE): Blood sample 2014 - 20184 years. Truth refers to whether the measure provided by the scores is able to measure what was intended [18]. Petri M CLOSED ANGLE/ ANGLE CLOSURE GLAUCOMA. What Does It Mean to Be a British Isles Lupus Assessment Group-Based doi: 10.1136/lupus-2022-000700. . , Bresee C Barr et al. In only one study [4], was PGA sensitivity assessed comparing the change with an anchor [109], represented by the treatment sensitive index: PGA sensitivity was found to be between that of the BILAG (highest sensitivity) and the SLEDAI (lowest sensitivity). The random effects model gives a more conservative estimate considering the heterogeneity. Reliability. [8] suggested the need for a disease activity instrument that would be valid, reliable and sensitive to change. , Esdaile JM. , Piette EW Piga M Flow chart illustrating the literature search and study selection. Improving patient pathways for systemic lupus erythematosus: a multistakeholder pathway optimisation study. Fanouriakis A , Block JA , Alarcn GS , Bouter LM , Bonithon-Kopp C et al. Use of Physician Global Assessment in systemic lupus - PubMed 25 (FIVE YEARS 8) Latest Documents Most Cited Documents Contributed Authors Related Sources Related Keywords Latest Documents; Most Cited Documents; Contributed Authors; Related Sources; Mina R Tel: 03 88 12 84 74; Fax: 03 88 12 82 90; E-mail: Measuring disease activity in adults with systemic lupus erythematosus: the challenges of administrative burden and responsiveness to patient concerns in clinical research, Patterns of disease activity in systemic lupus erythematosus, Novel evidence-based systemic lupus erythematosus responder index, Reliability and validity of six systems for the clinical assessment of disease activity in systemic lupus erythematosus, Failure to achieve lupus low disease activity state (LLDAS) six months after diagnosis is associated with early damage accrual in Caucasian patients with systemic lupus erythematosus, Treatment target in newly diagnosed systemic lupus erythematosus, 10 most important contemporary challenges in the management of SLE, Measurement of systemic lupus erythematosus activity in clinical research, Definition, incidence, and clinical description of flare in systemic lupus erythematosus. Systemic Lupus Erythematosus and Lupus Nephritis - Epidemiology The PGA is a well accepted and commonly used scale for evaluating treatment response in clinical trials both in adults and children. Convergent validity is fulfilled indirectly in studies where the PGA is used as the gold standard to assess the construct validity of other indices. Content validity. The Handheld Dermatoscope as a Nail-Fold Capillaroscopic Instrument - JAMA Three studies evaluated the association between PGA scores and treatment changes: PGA correlated negatively with adherence to treatment assessed through an item scale (r=0.31, P=0.11) [34]; clinically defined mild and moderate flares had a higher disease activity by the PGA (P<0.001) than those defined as mild/moderate flare only by medication changes [55]; PGA scores were associated positively with response to belimumab treatment (P=0.039) [43]. , Hochberg M. Wallace DJ et al. In two studies, the PGA-VAS was used to assess concepts other than disease activity: disease severity [4] and patients compliance with treatments [103]. SLE has protean and often complex manifestations, necessitating careful clinical assessment. Rendas-Baum R, Baranwal N, Joshi AV, Park J, Kosinski M. J Patient Rep Outcomes. RMD Open 2018;4:e000578. , Taghavi-Zadeh S et al. , Perez-Gutthann S The Physician Global Assessment (PGA) of treatment response measures the overall response to treatment as assessed by the physician. , Matos A The Physician Global Assessment (PGA) has been shown to be a valid, responsive, and feasible instrument to capture disease activity in systemic lupus erythematosus (SLE), but its low reliability further supports the need for a standardisation of its scoring. The PGA also showed good predictive validity, as it correlated significantly with measures of future outcomes, such as quality of life or laboratory exams, but no study has currently evaluated its correlation with measures of damage. If you have a published paper from this period that does not appear on this list, please contact Sue Marone, who will add it to next week's collection. et al. , Mazur M. Fatemi A Thanou A, Chakravarty E, James JA, Merrill JT. A PGA >1 was predictive of polymorphic light cutaneous eruption (P=0.02) [59] and correlated negatively with LLDAS attainment [37]. Methods: European League Against Rheumatism. 10- Medical- Surgical- Nursing- Intensive- Review , Landis RC . , Mokkink LB Physician's Global Assessment in Psoriatic Arthritis: A Multicenter Please check for further notifications by email. A high variability in scales was found, causing a wide range of reliability (intraclass correlation coefficient 0.670.98). Bethesda, MD 20894, Web Policies et al. Face validity was reported in all the articles retrieved in which the PGA was used alone or as part of composite indices (Systemic Responder Index, Safety of Estrogen in Lupus Erythematosus National Assessment Flare Index, Lupus Low Disease Activity State, Definitions of Remission in Systemic Lupus Erythematosus criteria). In one study, the PGA was part of a modified score to assess disease activity in pregnancy (the SLE in Pregnancy Disease Activity Index) [51]. et al. , Glassman DS Physician's global assessment is often useful in SLE - ResearchGate PGA - Lupus Research A good correlation was considered for a value >0.60. Physician's Global Assessment (PGA) score 1.0 on a 0 to 3 visual analog scale. Castrejn I, Ra-Figueroa I, Rosario MP, Carmona L. Reumatol Clin. For permissions, please email: [email protected], This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (. , Holland M , Andreoli L Observed and articulated management issues and responses. 2022 Sep 20;19(19):11895. doi: 10.3390/ijerph191911895. , Klein-Gitelman MS , McGuire JL. A good responsiveness for PGA was shown in eight studies. Complement-Targeted Therapeutics Market Report (2022 to PDF Physician global assessments for disease activity in rheumatoid physician global assessment Latest Research Papers | ScienceGate Criterion validity data reporting correlation coefficients between PGA and quality of life measures, laboratory markers and miscellaneous. Disclosure statement: L.A. is a consultant for Alexion, Amgen, AstraZeneca, GlaxoSmithKline, Janssen-Cilag, LFB, Eli Lilly, Menarini France, Novartis, Pfizer, Roche-Chugai and UCB. In 1988, Liang et al. The site is secure. Systemic lupus erythematosus (SLE), is the most common type of lupus. Quimby KR ~SLE~. , Tugwell P Dynabook PX1900E-1NCA, PROTECTIVE SLE (PX1900E-1NCA) , Floris A . may be asked to hyperventilate 3-4 min and watch a bright flashing light. , Borghoff K inflammation (duration and severity of morning stiffness as measured by BASDAI). OBJECTIVE The Physician Global Assessment (PGA) is a visual analogue score that reflects the clinician's judgement of overall SLE disease activity. New Tools to Measure Disease Activity in SLE - Rheumatology Network In most studies, the PGA was assessed by a rheumatologist experienced in SLE care or research and, as already stated, the ICC reliability was different for an untrained physician and a trained investigator [36]. National Library of Medicine allergy hx phenothiazines, cns depressants and stimulants withheld 48 hours prior. Oxford University Press is a department of the University of Oxford. , Jolly M. Ribi C 3TR (Taxonomy, Treatment, Targets and Remission) Systemic Lupus , Urowitz MB. An official website of the United States government. Mertz P, Piga M, Chessa E, Amoura Z, Voll RE, Schwarting A, Maurier F, Blaison G, Bonnotte B, Poindron V, Fiehn C, Lorenz HM, Korganow AS, Sibilia J, Martin T, Arnaud L. RMD Open. To discriminate between the severity of flares, the PGA was incorporated in a composite index: the SFI [10] (Table1). Ruiz-Irastorza G Reviews and case series with fewer than five patients were excluded. AU - Kandane-Rathnayake, Rangi. SLE is an immune-mediated multisystemic disease characterized by a wide variability of clinical manifestations and a course frequently subject to unpredictable flares [1, 2]. Vil LM , Fang H . The literature search identified 91 studies. At least 1 issue from each virtual tour. , Arora S Montreal, Canada Area. SFI, LLDAS, SRI, Definitions of Remission in Systemic Lupus Erythematosus remission criteria) [3, 5, 10, 1315, 104]. , Devilliers H It can affect the joints, skin, brain, lungs, kidneys, and blood vessels. The Physician Global Assessment (PGA) is an important tool for assessing disease activity in lupus. Prinsen CAC In Fatemi et al. To determine longitudinal associations between Physician Global Assessment (PGA) and patient-reported outcomes (PROs) in patients with systemic lupus erythematosus (SLE). Devilliers H et al. sharing sensitive information, make sure youre on a federal Lead Medical Director heading up the global collaboration with Pfizer for Enbrel trials. Once two investigators (E.C., M.P.) Notorious to increase IOP and cause severe PAIN and headache; Diagnostics: - History - Tonometry examinations - measures IOP QUESTION A client states that the physician has told her that her intraocular was 14. , Burlingame RW et al. This week's edition of Faculty Publications includes Cedars-Sinai studies that were published Feb. 23-March 2. et al. LECTURE 10: MEDICAL SURGICAL NURSING. Arriens C The index has proved quick and easy to use despite a comprehensive database and compares favourably with . One study, published after our systematic literature search was completed [112], showed that scoring the PGA with knowledge of laboratory data increased its correlation with the SLEDAI-2K (r=0.79) compared with without knowledge of laboratory results (r=0.67). , Giangreco D , Lau CS The literature search identified 91 studies. The search strategy for SSc-related publications identified 75 citations . Physician Global Assessment International Standardisation COnsensus in Systemic Lupus Erythematosus: the PISCOS study . The literature search identified 93 articles, and 12 additional articles were retrieved from the reference list of those publications. Physician training is very important. , Rairie JE et al. (PGA)and physician global assessment of disease activity (PHGA), C3, C4 and Anti-ds Anti-DNA titer abnormalities, and a formula incorporating the current . The LUMINA (Lupus in Minorities: Nature versus Nurture) study and other trials have offered evidence of a decrease in flares and prolonged life in patients given hydroxychloroquine, making . et al. The interRR was assessed in seven studies [4, 10, 11, 36, 65, 68, 94], showing values ranging from 0.67 [68] to 0.96 [94]. Five studies have demonstrated good ICC values for reliability (all >0.60 and ranging up to 0.97). A prospective cohort study, Validity and reliability of retrospective assessment of disease activity and flare in observational cohorts of lupus patients, A novel lupus activity index accounting for glucocorticoids: SLEDAI-2K glucocorticoid index, Low disease activityirrespective of serologic status at baselineassociated with reduction of corticosteroid dose and number of flares in patients with systemic lupus erythematosus treated with belimumab: a real-life observational study, Definition and initial validation of a lupus low disease activity state (LLDAS), A framework for remission in SLE: consensus findings from a large international task force on definitions of remission in SLE (DORIS), Prolonged remission in Caucasian patients with SLE: prevalence and outcomes, 2019 update of the EULAR recommendations for the management of systemic lupus erythematosus, PRISMA Group.
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